Effect of phenobarbitone on hepatic drug-metabolizing enzymes and urinary D-glucaric acid excretion in man.
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منابع مشابه
Urinary excretion of D-glucaric acid in porphyria cutanea tarda.
Twenty patients with porphyria cutanea tarda who had ingested no alcohol for at least 10 days before sampling were found to possess urinary D-glucaric acid levels similar to those of 30 clinically healthy controls. Correlation between urinary excretion of D-glucaric acid on the one hand and plasma or urinary porphyrin concentrations on the other was not statistically significant. These results ...
متن کاملValues for urinary excretion of D-glucaric acid by normal individuals.
The urinary excretion of D-glucaric acid reflects the activity of hepatic enzymes that hydroxylate and detoxify many substances foreign to the body. We measured it in 38 healthy unmedicated males (ages, 3 to 90 years; weights 11.8 to 136 kg) and in 15 females (ages, 10 to 80). The males, regardless of age or weight, excreted 56.1 ±15.7 (SD) nmol of D-glucaric acid per milligram of creatinine. A...
متن کاملExposure to toluene increases the urinary excretion of D-glucaric acid.
Workers at a printing plant exposed to low concentrations of toluene (43-401 mg/m3, median 155 mg/m3) had increased urinary D-glucaric acid (3.55-5.12 mmol/mol creatinine) excretion at the end of the shift compared with controls (2.45-3.35 mmol/mol creatinine). No increase was found after the summer holiday (1.92-2.89 mmol/mol creatinine) but excretion had increased two weeks later (4.05-5.55 m...
متن کاملEffects of Cyclamen Trochopteranthum on Hepatic Drug-metabolizing Enzymes
The modulatory effects of the Cyclamen trochopterantum tuber extract on hepatic drug-metabolizing enzymes, including aniline 4-hydroxylase (A4H; CYP2E1), ethoxyresorufin O-deethylase (EROD; CYP1A), methoxyresorufin O-demethylase (MROD; CYP1A), caffeine N-demethylase (C3ND; CYP1A2) aminopyrene N-demethylase (APND; CYP2C6), and erythromycin N-demethylase (ERND; CYP3A1), were examined in vivo in r...
متن کامل[Improvement of urinary d-glucaric acid assay and its application].
We propose an improved method to measure urinary D-glucaric acid (GA), which might be of value as an indirect index of the activity of cytochrome P450 (CYP). This method was about 20 times more sensitive than existing methods. Beer's law was obeyed in the concentration range 5.5-66 ng ml(-1) for GA, with the effective molar absorptivity at 533 nm and the relative standard deviation being 9.1 x ...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1975
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1975.tb01584.x